This morning’s attack on Kharkiv comes after a massive Russian barrage across Ukraine on Friday morning.
Updated figures show at least six people were killed and 80 injured, according to Ukrainian officials.
Three emergency responders died in a missile and drone salvo against the capital, Kyiv, said Volodymyr Zelenskyy.
Two were killed in an attack on the northern city of Chernihiv and at least one more in the northwestern city of Lutsk.
Russia said it was responding to Ukraine’s attacks on its strategic bombers.
Ukrainian foreign minister Andrii Sybiha said the response amounted to attacks on civilians, apartment blocks and energy infrastructure.
Russia used 407 drones, the air force said, one of the largest numbers recorded in a single attack.
Some 45 cruise and ballistic missiles were also fired, it added.